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產品資料

MERCK 681675-1MG Wortmannin

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產品名稱: MERCK 681675-1MG Wortmannin
產品型號: MERCK 681675-1MG
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MERCK 681675-1MG Wortmannin


MERCK 681675-1MG Wortmannin  的詳細介紹
MERCK 681675-1MG Wortmannin

Wortmannin

MERCK相關產品資料：

681675  Wortmannin ( Wortmannin )

KY 12420

A cell-permeable, fungal metabolite that acts as a potent, selective, and irreversible inhibitor of phosphatidylinositol 3-kinase in purified preparations and cytosolic fractions (IC50 = 5 nM). Blocks the catalytic activity of PI 3-kinase without affecting the upstream signaling events. Preincubation of fibroblasts with wortmannin abolishes PDGF-mediated Ins(3,4,5)P3 formation (IC50 = 5 nM). Also blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Inhibits MAP kinase activation induced by platelet activating factor in guinea pig neutrophils (200 - 300 nM). Also inhibits other kinases such as myosin light chain kinase (IC50 = 200 nM) and PI 4-kinase at concentrations higher than that required for inhibition of PI 3-kinase. Also blocks phospholipase D. A 10 mM (1 mg/233 µl) solution of Wortmannin (Cat. No. 681676) in DMSO is also available.

Product number

型號

價格

681675-1MG

1 mg

詢價

 

產品信息

Form

White to off-white solid

Primary Target

phosphatidylinositol-3-kinase

Primary Target IC50

5 nM

Secondary target

mlck (IC,sub>50 = 200 nM)

Molar mass

428.4

Protect from Light

Yes

Packaged under inert gas

Yes

Cell permeable

Yes

Purity

≥95% by HPLC

Solubility

DMSO or MeOH

Chemical formula

C23H24O8

RTECS

CB9641000

CAS number

19545-26-7

Merck USA index

14, 10053

 

Store and ship information

Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Storage

-20°C

Ship

Ambient Temperature Only
Highly Toxic

 

**標示

S Phrase

S: 22-36/37/39-45
Do not breathe dust.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

R Phrase

R: 26/27/28

 

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