Synonym:

2′-Deoxy-5-azacytidine, Decitabine, 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one

CAS Number:

2353-33-5

Linear Formula:

C₈H₁₂N₄O₄

Molecular Weight:

228.21

Beilstein Registry Number:

617982

EC Number:

219-089-4

MDL number:

MFCD00043011

PubChem Substance ID:

24890797

Frequently Asked Questions

Live Chat and Frequently Asked Questions are available for this Product.

Related Keywords

2′-Deoxy-5-azacytidine, Decitabine, Azadc, Aza dC, Dezocitidine, 4-Amino-1-(2-deoxy-beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, 5-Aza-2-deoxycytidine, epigenetic, ADC, 5-aza-CdR, 5-aza-dC,decitabine, demethylation, DNA, hypomethylating, chromatin, p53, p21, cip1, butryate, methylation

General description

Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling “opening” chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.

Biochem/physiol Actions

5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.

assay

≥97%

solubility

acetic acid: water (1:1): 50 mg/mL

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn

Risk Statements

22-36/37/38

Safety Statements

26

WGK Germany

3

RTECS

XZ3012000

品名

產地

貨號

規格

單價

地西他濱 Decitabine

Sigma

A3656

5MG

地西他濱 Decitabine

Sigma

A3656

10MG

地西他濱 Decitabine

Sigma

A3656

50MG