產品名稱：anti-mouse siglec H - marker for IPC/pDC plasmacytoid DC FITC eBio440c 50 ug 產品貨號：eBioscience 11-0333-81 產品規(guī)格：50 ug Anti-Mouse Siglec H FITC Also known as: Sialic Acid-Binding Immunoglobulin-Like Lectin H Clone: eBio440c RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 11-0333 Cat. No. Size 11-0333-81 50 ug 11-0333-82 100 ug Description: The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naïve mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG). It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.
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