產品名稱：Anti-Human/Mouse CD247 (CD3 zeta) PE (6B10.2) 25 ug
產品貨號：eBioscience 12-2479-80
產品規格：25 ug
Anti-Human CD247 (CD3 zeta) PE
Also known as: CD3z, TCR zeta
Clone: 6B10.2
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-2479
Cat. No. Size
12-2479-80  25 ug 
12-2479-82  100 ug 
Description: This 6B10.2 monoclonal antibody reacts with human CD247, which is also known as the invariant zeta chain. The CD3 complex is composed of three monomeric chains (γ, δ, and ε) and the invariant zeta chain, which exists as a homodimer or as a heterodimer with the η subunit. Together with the T cell antigen receptor (TCR), the CD3 γ, δ, ε, and zeta chains comprise the TCR/CD3 complex. CD3 zeta is expressed on immature and mature thymocytes, as well as T lymphocytes and NK cells. Signal transduction during T cell activation is mediated by tyrosine phosphorylation of cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) present on the zeta chain.
The 6B10.2 monoclonal antibody recognizes a transmembrane epitope of the CD3 zeta chain. Therefore, flow cytometric analysis with this antibody requires intracellular staining. In addition, this antibody has been reported to recognize the zeta chain as a homodimer but not as a monomer.
 

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