產(chǎn)品名稱：Anti-Mouse Bcl-6 PE (mGI191E) 25 ug 產(chǎn)品貨號(hào)：eBioscience 12-5760-80 產(chǎn)品規(guī)格：25 ug Anti-Mouse Bcl-6 PE Also known as: B cell lymphoma 6 Clone: mGI191E RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 12-5760 Cat. No. Size 12-5760-80 25 ug 12-5760-82 100 ug Description: This mGI191E monoclonal antibody reacts with mouse Bcl-6, which is also known as B-cell lymphoma 6. A member of the POZ family of transcriptional repressors, Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79-kDa protein is essential for germinal center B cell proliferation and survival. Moreover, during B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt’s lymphoma, and non-Hodgkin’s lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1.
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