產(chǎn)品名稱：Anti-Human/Mouse TOX PE (TXRX10) 100 ug 產(chǎn)品貨號：eBioscience 12-6502-82 產(chǎn)品規(guī)格：100 ug Anti-Human/Mouse TOX PE Also known as: Thymocyte selection-associated HMG box protein Clone: TXRX10 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 12-6502 Cat. No. Size 12-6502-80 25 ug 12-6502-82 100 ug Description: This TXRX10 monoclonal antibody reacts with human and mouse TOX, which is also known as Thymocyte selection-associated HMG box protein. This DNA-binding nuclear factor is expressed in thymocytes, T lymphocytes, NK cells, and lymphoid tissue-inducer (LTi) cells. TOX expression in thymocytes is upregulated during beta-selection and positive selection. Studies using Tox knockout mice have demonstrated a critical role for TOX in CD4+ T cell development as a regulator of the CD4loCD8lo to CD4+CD8lo transition. Moreover, TOX has been shown to be involved in the development of NK and LTi cells. While its regulation remains unclear, TOX expression has been shown to be induced by calcineurin-mediated TCR signaling in thymocytes during positive selection.
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