產(chǎn)品名稱(chēng)：anti-human/mouse Fn14/TWEAK Receptor (CD266) PE ITEM-4 100 ug 產(chǎn)品貨號(hào)：eBioscience 12-9018-82 產(chǎn)品規(guī)格：100 ug Anti-Human/Mouse CD266 (TWEAK Receptor) PE Also known as: TNFRSF12A , TWEAKR, Fibroblast growth factor-inducible 14, Fn14, Tumor necrosis factor ligand superfamily member 12 Clone: ITEM-4 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 12-9018 Cat. No. Size 12-9018-80 25 ug 12-9018-42 100 tests 12-9018-82 100 ug Description: The ITEM-4 antibody reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration. It has been reported that ITEM-4 cross-reacts with mouse Fn14. In the mouse, Fn14 is reported to be constitutively expressed by Colon 26 cell line.
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