產品名稱：anti-human CD230 (Prion protein) PE 4D5 100 tests
產品貨號：eBioscience 12-9230-73
產品規格：100 tests
Anti-Human CD230 (PrP) PE
Also known as: Prion protein
Clone: 4D5
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-9230
Cat. No. Size
12-9230-73  100 tests 
Description: CD230 (prion protein; PrPC) is a 35 kD glycoprotein, attached to the cell surface via a GPI-anchor. While the function of CD230 is unclear, prion protein has been the focus of research based on its involvement in transmissible spongiform encephalopathies (TSE), including Creutzfeld-Jakob disease in humans. CD230 undergoes a conformational change in which the cellular PrPC form is converted to the scrapie PrPSc form. This conversion is essential for the infectiousness of prion-based diseases. CD230 is predominantly expressed on the surface of lymphocytes and monocytes, with weak expression on granulocytes and erythrocytes. In platelets, CD230 is expressed primarily intracellularly, and is upregulated to the surface upon activation.
 

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