產品名稱：Biotin mouse CD172a (clone P84), 25 ug
產品貨號：eBioscience 13-1721-80
產品規格：25 ug
Anti-Mouse CD172a (SIRP alpha) Biotin
Also known as: SHPS-1, Signal-regulatory protein alpha-1
Clone: P84
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 13-1721
Cat. No. Size
13-1721-80  25 ug 
13-1721-82  100 ug 
Description: This P84 monoclonal antibody reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.
This monoclonal antibody has been reported to have neutralizing activity.
 

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