產品名稱：E-Cadherin (clone DECMA-1), 100 ug
產品貨號：eBioscience 13-3249-82
產品規格：100 ug
Anti-CD324 (E-Cadherin) Biotin
Also known as: epithelial cadherin
Clone: DECMA-1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 13-3249
Cat. No. Size
13-3249-80  25 ug 
13-3249-82  100 ug 
Description: The monoclonal antibody DECMA-1 recognizes mouse, human and canine CD324 also known as E-cadherin (Epithelial cadherin) or uvomorulin. Like the other cadherin family members P and N cadherin, E-cadherin is a transmembrane glycoprotein involved in intercellular adhesion. These proteins share a common basic structure. The extracellular portions of the proteins are largely composed of repeating domains, each with two consensus Ca2+-binding motifs. The cytoplasmic domain interacts with a-, b-, and g-catenins and actinins. These catenins connect E-cadherin with the cytoskeleton.
Expression is found in most epidermal cells including melanocytes and kerotinocytes. E-cadherin is localized at the intercellular boundaries of epithelial cells in several tissues, and is thought to play a role in maintenance of tissue integrity. Loss of E-cadherin function has been implicated in the progression of a variety of cancers.
E-Cadherin protein is sensitive to trypsin treatment, so exposure to trypsin should be minimized or avoided.
The monoclonal antibody DECMA-1 has been shown to have functional activity by disrupting adhesion in human, mouse and dog cells.
 

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