產(chǎn)品名稱：anti-mouse LPAM-1 (Integrin a4b7) Biotin DATK32 (DATK-32) 500 ug 產(chǎn)品貨號：eBioscience 13-5887-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse Integrin alpha 4 beta 7 (LPAM-1) Biotin Also known as: LPAM1, Integrin alpha4 beta7, Integrin alpha4beta7 Clone: DATK32 (DATK-32) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 13-5887 Cat. No. Size 13-5887-81 50 ug 13-5887-82 100 ug 13-5887-85 500 ug Description: The DATK32 monoclonal antibody binds to a combinatorial epitope of mouse LPAM-1 (α4β7), which is a heterodimer of the the 154 kDa α4 subunit and the 130 kDa β7 subunit. In mouse, the β7 subunit is found on the majority of mature lymphocytes and a small population of thymocytes and bone marrow cells. LPAM-1 is an integrin involved in the transendothelial migration of lymphocytes across high endothelial venules (HEV), and is know to bind several ligands including MAdCAM-1, VCAM-1 and fibronectin. Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block LPAM-1-mediated cell adhesion.
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