產品名稱：anti-mouse BTLA / CD272 (Non-Blocking) Biotin 8F4 25 ug
產品貨號：eBioscience 13-5956-80
產品規格：25 ug
Anti-Mouse CD272 (BTLA) Biotin
Also known as: B and T lymphocyte attenuator
Clone: 8F4
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 13-5956
Cat. No. Size
13-5956-80  25 ug 
13-5956-82  100 ug 
Description: The BTLA antibody reacts with mouse BTLA, B and T lymphocyte attenuator from both BALB/c and C57Bl/6 strains. BTLA is expressed by peripheral lymphocytes, splenic macrophages, developing B cells in the bone marrow and developing T cells in thymus and mature, but not immature bone marrow-derived dendritic cells. BTLA is implicated as a negative regulator of the activation and/or function of various hemopoietic cell types. It is reported that BTLA binds to B7-H4, but further studies are needed to confirm this interaction.
Note: The anti-mouse BTLA monoclonal antibody 6F7 is reported to stain CD4+ and CD8+ single-positive (SP) thymocytes (Hurchla et al). However, other anti-mouse BTLA clones generated simultaneously with 6F7 (8F4, 3F9.D12, 6G3 and 6H6) do not stain SP thymocytes . It is not understood why there is a discrepancy in thymocyte staining. However, in staining of splenocytes and bone marrow cells, clones 8F4, 3F9.D12, 6G3 and 6H6 stain similar populations to 6F7.
 

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