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anti-human CD152 Purified 14D3 **

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產品名稱: anti-human CD152 Purified 14D3 **
產品型號: 14-1529-82
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anti-human CD152 Purified 14D3 **


anti-human CD152 Purified 14D3 **  的詳細介紹
anti-human CD152 Purified 14D3 **

產品名稱:anti-human CD152 Purified 14D3 100 ug
產品貨號:eBioscience 14-1529-82
產品規格:100 ug
Anti-Human CD152 (CTLA-4) Purified
Also known as: CTLA4
Clone: 14D3
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-1529
Cat. No. Size
14-1529-80  25 ug 
14-1529-82  100 ug 
Description: The 14D3 monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling.

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