Purified mouse CCL19-Fc (ELC, MIP3b, CKb11) **
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產(chǎn)品名稱: Purified mouse CCL19-Fc (ELC, MIP3b, CKb11) **
產(chǎn)品型號(hào): 14-1972-63
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Purified mouse CCL19-Fc (ELC, MIP3b, CKb11) **
Purified mouse CCL19-Fc (ELC, MIP3b, CKb11) **
的詳細(xì)介紹
Purified mouse CCL19-Fc (ELC, MIP3b, CKb11) **
產(chǎn)品名稱：Purified mouse CCL19-Fc (ELC, MIP3b, CKb11) 10 ug
產(chǎn)品貨號(hào)：eBioscience 14-1972-63
產(chǎn)品規(guī)格：10 ug
Mouse CCL19-Fc (MIP-3 beta) Fusion Recombinant Protein
Also known as: ELC, MIP3b, CKb11
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-1972
Cat. No. Size
14-1972-63 10 ug
Description: The purified mouse CCL19-Fc is a fusion protein of the mouse CCL19 chemokine with the human Fcγ fragment. The purified mouse CCL19-Fc can be used for the detection of mouse CCR7 expression when used with a fluorochrome-conjugated anti-human Fc antibody. CCR7 is a chemokine receptor for the chemokines CCL19 (CKβ11, ELC, MIP3β, Scya19, Exodus-3) and CCL21 (CKβ9, SLC, MIP2β, Scya21, Exodus-2). In recent years, the role of chemokines in directing the migration of lymphocytes has been well-characterized. One of the most important mediators of homeostatic trafficking of naïve T cells to secondary lymphoid organs (SLO) is the chemokine receptor CCR7. Binding of its ligands, CCL19 and CCL21, mediates the transendothelial migration of T cells across high endothelial venules into SLO. It has also been demonstrated that CCR7 plays a role in the localization of dendritic cells and B cells during an immune response.
In addition to its significant role in the chemotaxis of lymphocytes, human CCR7 has also been recognized as a marker for a distinct subset of memory T cells, the central memory (TCM) population. These cells are characterized by the expression of CCR7 and CD62L and reside within peripheral lymphoid organs.
CCR7 also plays a role in thymocyte development and its deficiency leads to disturbed thymic architecture, aberrant T cell development, and limited thymocyte expansion.
