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anti-mouse PIM-2 Purified (Clone: 1D12) **

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產品名稱: anti-mouse PIM-2 Purified (Clone: 1D12) **
產品型號: 14-3308-82
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anti-mouse PIM-2 Purified (Clone: 1D12) **


anti-mouse PIM-2 Purified (Clone: 1D12) **  的詳細介紹
anti-mouse PIM-2 Purified (Clone: 1D12) **

產品名稱:anti-mouse PIM-2 Purified (Clone: 1D12) 100 ug
產品貨號:eBioscience 14-3308-82
產品規格:100 ug
Anti-Mouse PIM-2 Purified
Also known as: PIM2, PIM 2
Clone: 1D12
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-3308
Cat. No. Size
14-3308-80  25 ug 
14-3308-82  100 ug 
Description: This ID12 monoclonal antibody reacts with mouse PIM-2, a member of a family of serine/threonine kinases. In the mouse, Pim-2 exists as three isoforms (34-, 38-, and 40-kDa) due to alternative translation initiation. Pim-2 is expressed in hematopoietic cells and overexpressed in prostate cancer, leukemia, and lymphoma. Regulated transcriptionally by the JAK/STAT pathway, Pim-2 is induced by IL-2 and IL-3. This kinase plays a role in cell survival by inhibiting the pro-apoptotic Bcl-2 family member Bad via phosphorylation and by blocking caspase-3 activation. Expression of Pim-2 has also been shown to confer rapamycin resistance in T lymphocytes. 
 

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