產(chǎn)品名稱：anti-mouse / human T-bet Purified eBio39D (39D, 3-9D) 100 ug 產(chǎn)品貨號：eBioscience 14-5824-82 產(chǎn)品規(guī)格：100 ug Anti-T-bet Purified Also known as: Tbet, Th1-specific T box transcription factor, T-box Clone: eBio39D (39D, 3-9D) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-5824 Cat. No. Size 14-5824-80 25 ug 14-5824-82 100 ug Description: The eBio39D monoclonal antibody reacts with mouse, rat and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN-γ, and T-Bet also regulates the expression of IFN-γ, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN-γ, T-Bet is also known to regulate the expression of IL-12Rβ and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells.
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