產(chǎn)品名稱：anti-human B7-DC (CD273) Purified MIH18 100 ug 產(chǎn)品貨號：eBioscience 14-5888-82 產(chǎn)品規(guī)格：100 ug Anti-Human CD273 (B7-DC) Purified Also known as: B7DC, PDCD1LG2, Btdc, PDL2, PD-L2, PDCD1L2 Clone: MIH18 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-5888 Cat. No. Size 14-5888-80 25 ug 14-5888-82 100 ug Description: The MIH18 monoclonal antibody reacts with human B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25 kDa and belongs to the Ig superfamily. B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. MIH18 is a useful tool for studies to elucidate the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in humans. MIH18 is a blocking antibody.
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