產(chǎn)品名稱：Anti-Human NG2 Purified (9.2.27), 100 ug 產(chǎn)品貨號：eBioscience 14-6504-82 產(chǎn)品規(guī)格：100 ug Anti-Human Neural/Glial Antigen 2 (NG2) Purified Also known as: Chondroitin Sulfate Proteoglycan, MCSP/melanoma chondroitin sulfate proteoglycan Clone: 9.2.27 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-6504 Cat. No. Size 14-6504-80 25 ug 14-6504-82 100 ug Description: This 9.2.27 monoclonal antibody reacts with human neural/glial antigen 2, which is also known as melanoma chondroitin sulfate proteoglycan (MCSP). This antigen is composed of a 250 kDa N-linked glycoprotein and a >450 kDa proteoglycan. NG2 is present on the surface of >90% of malignant melanomas in addition to some non-melanomic tumors. Moreover, NG2 is expressed on glioma cells, as well as on developing and ***** oligodendrocyte precursor cells. Studies have demonstrated the involvement of this protein in tumor cell proliferation, adhesion, migration, and invasion. NG2 also functions as a coreceptor for alpha4beta1 integrin. Finally, expression of NG2 can be used as a prognostic marker for disorders such as acral letiginous melanoma and infantile acute myeloid leukemia. The 9.2.27 antibody has been reported to suppress melanoma tumor growth.
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