產(chǎn)品名稱：Anti-Human Chorionic Gonadotropin Purified (FB12) 100 ug 產(chǎn)品貨號：eBioscience 14-6508-82 產(chǎn)品規(guī)格：100 ug Anti-Human Chorionic Gonadotropin Purified Clone: FB12 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-6508 Cat. No. Size 14-6508-80 25 ug 14-6508-82 100 ug Description: This FB12 monoclonal antibody reacts with human Chorionic Gonadotropin (hCG). This secreted glycoprotein is composed of an alpha subunit, which is common to other peptide hormones such as luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroid stimulating hormone (TSH), and a beta subunit which determines the specificity of the hormone. FB12 recognizes both the intact hCG (composed of the alpha and beta subunits) as well as the free beta subunit, highly expressed in both choriocarcinoma and the serum of pregnant women. hCG is normally expressed by trophoblastoid cells (syncytiotrophoblasts and extravillous cytotrophoblasts) that are responsible for maintenance of the corpus luteum during early gestation. hCG plays an important role in the regulation of angiogenesis through activation of the PI3K/mTOR pathway, resulting in upregulation of vascular endothelial growth factor (VEGF). Ectoptic expression of hCG has also been reported in multiple types of cancer (bladder, lung, breast, pancreas, renal).
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