產(chǎn)品名稱：anti-mouse Bcl-3 Purified Ham150-3.5 100 ug 產(chǎn)品貨號：eBioscience 14-6903-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse Bcl-3 Purified Also known as: B-cell lymphoma/leukemia-3, BCL3, BCL4 Clone: Ham150-3.5 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-6903 Cat. No. Size 14-6903-80 25 ug 14-6903-82 100 ug Description: The Ham150-3.5 antibody reacts with mouse and human Bcl-3. Bcl-3 is a member of the IκB multigene family, which modulates the activities of NF-κB/Rel transcription factors. Bcl-3 is reported to increase transcription from NF-κB responsible promoters and to dissociate p50-p52 homodimers from DNA. Bcl-3 is phosphorylated influencing its interaction with both p50 and p52. Bcl-3 was cloned from a chromosomal breakpoint in the t(14;19) translocation, which is found in some cases of chronic B-cell lymphocytic leukemias. Bcl-3 is required for T-cell-dependent immunity. Bcl-3-deficient mice are defective in antigen-specific antibody production and germinal-center formation and fail to resist infection. Bcl-3 may also contribute to B-cell survival, which may explain its oncogenic potential when expressed at high levels as result of chromosomal translocation. Bcl-3 is detected in different tissues, especially the spleen and other lymphoid organs. The gene was shown to be induced by mitogenic stimuli in B and T cells and by cytokines on human erythroid precursors. It is shown that Bcl-3 expression is able to block apoptosis in IL-4-deprived cells.
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