產品名稱：Recombinant mouse LIF, 25 ug
產品貨號：eBioscience 14-8521-80
產品規格：25 ug
Mouse LIF Recombinant Protein
Also known as: leukocyte inhibitory factor, Leukemia inhibitory factor
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-8521
Cat. No. Size
14-8521-62  5 ug 
14-8521-80  25 ug 
Description: Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.

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