產(chǎn)品名稱(chēng)：Recombinant Mouse M-CSF 25 ug 產(chǎn)品貨號(hào)：eBioscience 14-8983-80 產(chǎn)品規(guī)格：25 ug Mouse M-CSF Recombinant Protein Also known as: Macrophage colony stimulating factor, monocyte colony stimulating factor, CSF-1, MCSF RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-8983 Cat. No. Size 14-8983-62 5 ug 14-8983-80 25 ug Description: Macrophage colony-stimulating factor (M-CSF or CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. The secreted protein is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex.
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