產(chǎn)品名稱：anti-human PD-1 (CD279) Purified J116 100 ug 產(chǎn)品貨號：eBioscience 14-9989-82 產(chǎn)品規(guī)格：100 ug Anti-Human CD279 (PD-1) Purified Also known as: PD1 Clone: J116 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9989 Cat. No. Size 14-9989-80 25 ug 14-9989-82 100 ug Description: The J116 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55 kDa member of the immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.
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