產品名稱：Anti-Human CD184 (CXCR4) PE-Cy5 (12G5) 100 tests
產品貨號：eBioscience 15-9999-42
產品規格：100 tests
Anti-Human CD184 (CXCR4) PE-Cy5
Also known as: C-X-C chemokine receptor type 4, Fusin, SDF-1 receptor
Clone: 12G5
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 15-9999
Cat. No. Size
15-9999-41  25 tests 
15-9999-42  100 tests 
Description: The 12G5 monoclonal antibody reacts with human CXCR4 (CD184), also termed Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CXCR4 is expressed predominantly on naive T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. 12G5 shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CXCR4), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.

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