產(chǎn)品名稱：Anti-human ILT1 (CD85h, LIR7) (135.4) 500 ug 產(chǎn)品貨號：eBioscience 16-5119-85 產(chǎn)品規(guī)格：500 ug Anti-Human CD85h (ILT1) Functional Grade Purified Also known as: ILT-1, LIR7, LILRA2 Clone: 135.4 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-5119 Cat. No. Size 16-5119-82 100 ug 16-5119-85 500 ug Description: The monoclonal antibody 135.4 recognizes ILT1, also known as CD85h, LIR7 and LILRA2. ILT1 is a member of the large family of ILT molecules (Immunologulin-like Transcripts) also known as Leukocyte Ig-like Receptors (LIRs) and Monocyte/Macrophage Ig-like Receptors (MIRs). ILT1 contains a short cytoplasmic domain. Through the cytoplasmic domain ILT1 associates with the Fc receptor gamma chain but not DAP12 resulting in a stimulatory signal. ILT1 may act as a receptor for MHC Class I antigens. Expression of ILT1 is mainly found on monocytes, macrophages, DC and weakly on granulocytes. ILT1 is thought to play a role in the TH1/Th2 balance as well as TLR signaling. The monoclonal antibody 135.4 has been reported to have activating properties upon crosslinking which result in calcium influx.
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