Anti-Mouse gp49 Receptor (clone H1.1) Functional Grade Purified, **
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產品名稱: Anti-Mouse gp49 Receptor (clone H1.1) Functional Grade Purified, **
產品型號: 16-5784-85
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Anti-Mouse gp49 Receptor (clone H1.1) Functional Grade Purified, **
Anti-Mouse gp49 Receptor (clone H1.1) Functional Grade Purified, **
的詳細介紹
Anti-Mouse gp49 Receptor (clone H1.1) Functional Grade Purified, **
產品名稱：Anti-Mouse gp49 Receptor (clone H1.1) Functional Grade Purified, 500 ug
產品貨號：eBioscience 16-5784-85
產品規格：500 ug
Anti-Mouse gp49 Receptor Functional Grade Purified
Clone: H1.1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 16-5784
Cat. No. Size
16-5784-85 500 ug
Description: The monoclonal antibody H1.1 recognizes gp49, a receptor with structural similarities to the PIR (paired Ig-activating receptors) and ILT/KIR(killer inhibitory receptors) family of proteins. Two closely linked genes on mouse chromosome 10 encode the related proteins gp49A and gp49B. These two receptors are almost 90% identical in their extracellular regions but differ in their cytoplasmic domains; gp49B contains an ITAM domain while gp49A does not and is extremely short. Expression of gp49 was originally identified on mast and LAK (IL-2 activated NK) cells. Expression on LAK cells has been shown to be predominantly gp49B with only a small amount of gp49A. Additionally gp49 is found on myeloid cells. Detailed function is not known but gp49B can inhibit cellular activation. The monoclonal antibody H1.1 recognizes both gp49A and gp49B. The H1.1 antibody has been shown to have functional activity: when crosslinked along with anti-NK1.1 it can prevent cytokine release in KY-2 cells.
