產(chǎn)品名稱：Anti-Human CD201 (EPCR) (clone RCR-227) APC, 100 tests 產(chǎn)品規(guī)格：eBioscience 17-2018-42 產(chǎn)品貨號：100 tests Anti-Human CD201 (EPCR) APC Also known as: Endothelial protein C receptor Clone: RCR-227 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-2018 Cat. No. Size 17-2018-41 25 tests 17-2018-42 100 tests Description: The monoclonal antibody RCR-227 reacts with human CD201, which is also known as the endothelial protein C receptor (EPCR), a 46-kDa transmembrane protein related to class I MHC. CD201 was originally identified on vascular endothelium cells, predominantly larger blood vessels. It is also expressed on monocytes, lymphocytes, hematopoietic stem cells, neutrophils, and eosinophils. CD201 serves as a binding site for protein C, activated protein C (APC), and factor VII/VIIa. A soluble form has also been identified in the plasma. CD201 plays a role in controlling coagulation as disruption of its gene in mice caused placental thrombosis and early embryonic death. This cell surface molecule is also involved in the anti-inflammatory response. APC binding to CD201 enables PAR-1 activation that confers cytoprotective effects. In monocytes, APC binding decreases secretion of proinflammatory cytokines, chemokines, and growth factors. Finally, CD201 has been shown to inhibit lymphocyte migration.
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