產(chǎn)品名稱：Anti-Mouse IL-1 beta (Pro-form) APC (NJTEN3) 25 ug 產(chǎn)品貨號：eBioscience 17-7114-80 產(chǎn)品規(guī)格：25 ug Anti-Mouse IL-1 beta Pro-form APC Also known as: Interleukin-1 beta, IL-1F2 Clone: NJTEN3 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-7114 Cat. No. Size 17-7114-80 25 ug Description: This NJTEN3 monoclonal antibody reacts with the pro-form of mouse IL-1β, which is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1β into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1β. IL-1β lacks a signal sequence peptide for classical ER/Golgi pathway and is instead secreted alongside caspase-1 via an alternate and incompletely understood mechanism. IL-1β signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1α. These cytokines play important roles in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. Their activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Elevated levels of IL-1β have been associated with many chronic inflammatory conditions, giving IL-RA or IL-1β neutralizing antibodies potential therapeutical value. The NJTEN3 antibody recognizes only the pro-form of mouse IL-1β and does not see the active (cleaved) form.
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