產(chǎn)品名稱：Anti-Human Bcl-6 (clone BCL-UP) APC, 100 tests 產(chǎn)品貨號：eBioscience 17-9880-42 產(chǎn)品規(guī)格：100 tests Anti-Human Bcl-6 APC Also known as: B-cell lymphoma 6 Clone: BCL-UP RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-9880 Cat. No. Size 17-9880-41 25 tests 17-9880-42 100 tests Description: The monoclonal antibody BCL-UP recognizes Bcl-6, also known as B-cell lymphoma 6,which is a member of the POZ family of transcriptional repressors. Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79 kDa protein is essential for germinal center B cell proliferation and survival. During B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt’s lymphoma, and non-Hodgkin’s lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1.
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