產(chǎn)品名稱：Human IL-8 Single-Use ELISA RSG Standard 4 pack 產(chǎn)品貨號(hào)：eBioscience 39-8089-65 產(chǎn)品規(guī)格：4 Pack Human IL-8 Single-Use ELISA RSG Standard Also known as: Interleukin-8, CXCL8 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 39-8089 Cat. No. Size 39-8089-65 4 pack Description: Human IL-8 (CXCL8) is a pro-inflammatory member of the CXC chemokine family. It is synthesized as a 99 amino acid precursor protein that is further processed into one of four isoforms, with the most common being 72 or 77 amino acids in length. IL-8(77) is secreted primarily by endothelial cells and is thought to be a less potent neutrophil activator than the other forms. It is present at high levels during fetal development, where it mediates angiogenesis rather than inflammation. The predominant form present in *****s is IL-8(72), which is expressed by monocytes, macrophages, epithelial cells, and fibroblasts in response to inflammatory stimuli, environmental stress, and steroid hormones. IL-8(72) is essential for the activation and recruitment of neutrophils to sites of inflammation, and has also been found to influence T cell migration. Signaling occurs through the G-protein coupled receptors CXCR1 or CXCR2. IL-8 transcripts are often upregulated in tumors, and it is associated with tumor angiogenesis and metastasis.
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