產(chǎn)品名稱：Recombinant Mouse IL-15/15R Complex ELISA Standard, 4 pack 產(chǎn)品貨號(hào)：eBioscience 39-8152-65 產(chǎn)品規(guī)格：4 Pack Recombinant Mouse IL-15/IL-15R Complex Single-Use ELISA RSG Standard Also known as: Interleukin 15, IL15, IL-15 receptor, IL-15 receptor/ligand complex RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 39-8152 Cat. No. Size 39-8152-65 4 pack Description: Interleukin-15 (IL-15) is a 14 kDa proinflammatory protein that has been shown to play a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential to the development and survival of NK cells and CD8 T-cells. IL-15 activates Jak/Stat pathways by signaling through a heterotrimeric receptor. Two of the subunits of this receptor, beta and gamma, are shared with the IL-2 receptor, while the alpha subunit is unique to IL-15. Despite the expression of IL-15 mRNA in many cell types, the secreted protein is rarely detectable in biological samples. Recent research suggests that IL-15 is retained inside the cell and is only secreted in complex with its unique receptor, IL-15R alpha. This chaperoning is required from the ER to Golgi through to secretion. The cytokine/receptor complex may stay bound to the cell surface, where it can be trans-presented to cells expressing the beta/gamma subunits of the receptor, or may be secreted in a soluble form that lacks the transmembrane domain of the receptor. The soluble IL-15/IL-15R complex is produced by mouse dendritic cells, fibroblasts, and macrophages, and demonstrates a 10-100-fold increase in agonistic activity over IL-15 alone.
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