Cyclosporin A **
產品名稱：Cyclosporin A
產品貨號：Affix AF3001
產品規格：500 mg
Technical Data
Chemical Name 30-ethyl-33-(1-hydroxy-2-methylhex-4-enyl)-1,4,7,10,12,15,19,25, 28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1, 4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17, 20,23,26,29,32-undecone
Biological Description Cyclosporin A (cyclosporine, cyclosporin , CsA) is an immunosuppressant agent widely used in post-allogeneic organ transplant to reduce the activity of the immune system. A metabolite of the fungi Trichoderma polysporum, Cyclosporin A (CsA) is a cyclic polypeptide consisting of 9 amino-acids to inhibit nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. CsA is an immunosuppressant.The CsA-cyclophilin complex inhibits calcineurin, a type 2B phosphatase. It is an important diagnostic tool for the characterization of permeability transition-related phenomena. It inhibits mitochondrial permeability transition pore opening however, pore inhibition becomes less efficient at increasing Ca2+ loads and inhibition is transient.
Molecular Weight 1202.64
Molecular Formula C62H111N11O12
Solubility Soluble in ethanol (30 mg/ml) and to 100 mM in DMSO.
Purity >98 %
Storage instructions Desiccate at -20°C
CAS No. 59865-13-3
References Seaton, T.A., et al. 1998. Brain Res. 809: 12-17.Kruman, I.I. and Mattson, M.P. 1999. J. Neurochem. 72: 529-540.
