產品名稱：Phorbol 12-Myristate 13-Acetate, >99.5%
產品貨號：LC  P-1680
產品規格：10 MG
This is the most commonly used phorbol ester.  It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues, and is a very potent mouse skin tumor promoter.  Blumberg, P.M.  "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1."  Crit. Rev. Toxicol. 8:  153-197 (1980) and Blumberg, P.M.  "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2."  Crit. Rev. Toxicol. 8:  199-234 (1980).
Although PMA is quite toxic, it has shown anti-leukemic and anti-neutropenic activity in humans.  Han, Z.T. et al.  "Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity."  Proc. Natl. Acad. Sci. USA 95:  5357-5361 (1998) and Han, Z.T. et al.  "12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs."  Proc. Natl. Acad. Sci. USA 95:  5362-5365 (1998).
Beginning with our lot #F-151, we now guarantee purity of 99.5% or greater for this product as measured by HPLC at 254nm.
Please request Technical Note #14 for additional information.
WARNING:  Highly irritant to skin and mucous membranes.  SPECIAL HAZARD:  TUMOR PROMOTER.  Gloves and mask should be worn when using this compound.  Care must be taken to prevent contact through all routes of exposure.
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO or ethanol.  Disposal:  A

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