產品名稱：StemRegenin 1, Free Base
產品貨號：LC  S-2440
產品規格：100 MG
StemRegenin 1 (SR1) is a purine derivative that promoted ex vivo expansion of CD34+ cells, with an EC50 of ~120 nM after treatment for 5 to 7 days.  It induced a 17-fold increase in cells capable of long-term hematopoietic repopulation when transplanted into immunodeficient mice.  SR1 did not induce proliferation without cytokines, and inhibited proliferation at concentrations above 1 µM.  SR1 expanded CD34+ cells from bone marrow of humans, monkeys and dogs, but not mice.  SR1 promoted the retention of CD34 expression and multilineage potential after ex vivo culture.  It also expanded the number of colony-forming units.  SR1 may act by antagonizing the aryl hydrocarbon receptor.  Boitano, A.E., et al.  "Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells."  Science 329:  1345-1348 (2010).
Discovery of SR1 is a significant step towards the goal of ex vivo expansion of human hematopoietic stem cells (HSC) for patients in need of HSC transplantation.  Sauvageau, G. and Humphries, R.K.  "The blood stem cell Holy Grail?"  Science 329:  1291-1292 (2010).
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO.  Disposal:  A

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