產品名稱：Paxilline
產品貨號：Affix  AF3004
產品規格：5 MG
Technical Data
Chemical Name：(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,1 4a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b ,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]in deno[1,2-b]indol-3(4bH)-one.
Biological Description：Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels.Paxilline is a potent blocker of high-conductance Ca 2+ -activated K + (BK Ca ) channels. Binds to the α -subunit of BK Ca (K i = 1.9 nM for block of currents in α -subunit-expressing oocytes) and enhances binding of charybdotoxin to BK Ca channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca 2+ -ATPase (IC 50 = 5-50 μ M).
Molecular Weight 435.6
Molecular Formula C27H33NO4
Solubility Soluble in 100 mM in DMSO and to 20 mM in ethanol and DMSO
Purity >98 %
Storage instructions Desiccate at -20°C
CAS No. 57186-25-1
References Femling, J.K., et al. 2006. J. Gen. Physiol. 127: 659-672.
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