Rapamycin
產品名稱： Rapamycin
產品貨號：Affix AF3029
產品規格：5 mg
Technical Data
Chemical Name (3S,6R,7E,9R,10R,12R,14S,15E,17E,19 E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24, 25, 26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3- [(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl] -1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-he xamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacy clohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
Biological Description Rapamycin is a member of the macrolide immunosuppressant family, rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities. Specific inhibitor of mTOR Complexes with FKBP-12 and binds mTOR inhibiting its activity. Inhibits interleukin-2-induced phosphorylation and activation of p70 S6 kinase.
Molecular Weight 914.2 daltons.
Molecular Formula C51H79NO13
Solubility Soluble in DMSO and ethanol (up to 50 mg/ml)
Purity >99%
Storage instructions Up to one week at 4°C or six months at -20°C.
CAS No. 53123-88-9
References Aimee L. Edinger, et al. (2003) Cancer Res. 63, 8451.
