產品名稱：Bortezomib
產品貨號：Affix  AF3037
產品規格：25 mg
Technical Data
Chemical Name [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2- [(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic acid; Velcade; DPBA
Biological Description Bortezomib is a selective and robust 26S proteasome inhibitor, that is a boronic acid dipeptide derivative. Targeted elimination of damaged or unwanted proteins via the ubiquitin-proteasome pathway is fundamental to the control of many essential cell functions, including cell-cycle progression, gene transcription, and apoptosis. Bortezomib has been reported to inhibit necrosis and cell proliferation, and downregulate metastatic gene expression.
Molecular Weight 384.24 daltons
Molecular Formula C19H25BN4O4
Solubility Soluble in Chloroform, Dimethyl Sulfoxide, Methanol and Ethanol 
Purity >99%
Storage instructions Up to one week at 4°C or six months at -20°C.
CAS No.  179324-69-7 
References Jones, M.D., et al. 2010. Clin. Cancer Res. 16

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