Paclitaxel
產品名稱：Paclitaxel
產品貨號：Affix AF3051
產品規格：50 mg
Technical Data
Chemical Name [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Biological Description Paclitaxel (Taxol) is a microtubule polymer stabilizer with an IC50 of 0.1 pM for human endothelial cells. It selectively inhibits the proliferation of human endothelial cells (ECs) at ultra low concentrations (0.1-100 pM), while it inhibits non-endothelial type human cells at 10(4) - to 10(5) -fold higher concentrations, with IC50 = 1-10 nM. (Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest)
Molecular Weight 853.9 daltons
Molecular Formula C47H51NO14
Solubility Soluble in Ethanol and DMSO
Purity >99%
Storage instructions Up to one week at 4°C or six months at -20°C.
CAS No. 33069-62-4
References Park et al (2004) Taxol induces caspase-10-dependent apoptosis. J.Biol.Chem. 279 51057.
