產品名稱：K252a
產品貨號：Affix  AF3065
產品規格：1 mg
Technical Data
Chemical Name 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-.
Biological Description K252a inhibits a variety of kinases including PKC (IC50 = 25 nM), PKA (IC50 = 18 nM) and PKG (IC50 = 20 nM)1. It also inhibits CaMK (IC50 = 1.8 nM) and MLCK (IC50 = 17 nM). K252a has also been shown to inhibit NGF mediated proliferation through Trk receptor family2.
Molecular Weight 467 daltons
Molecular Formula C27H21N3O5
Solubility Soluble in DMSO (1 mg/ml) and DMF (1 mg/ml)
Purity >98 %
Storage instructions Up to one week at 4°C or six months at -20°C.
CAS No. 97161-97-2
References Tapley, P. et al. (1992) Oncogene 7, 371.

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