產品名稱：VMA ELISA
產    地：Demeditec 
產品貨號：DE1620
產品規格：96 Tests
產品說明：
Special remarks:
1 Name and Intended Use
The VMA ELISA is designed for in vitro quantitative measurement of vanillylmandelic acid (VMA) concentration in patients’ urine.
For in vitro diagnostic use only.
2 Background
Among spectrophotometric procedures the most widely used procedure was developed by Pisano et al (1) measuring vanillin directly at 360 nm. The colorimetric methods in general, however, suffer from interfering compounds and intensive labor requiring a number of manual steps. The use of paper chromatographic methods (2,3) employing diazotized p-nitroanilline and a thin layer chromatographic (TLC) procedure on silica gel (4) were reported for the analysis of extracted VMA but are considered to be of only historical interest. More recently, high performance liquid chromatography (HPLC) procedures are reported using a variety of detectors including ultraviolet light (5-7), amperometirc detection (8-11), and postcolumn reaction (12, 13). These procedures are considered to be a considerable improvement for overall specificity and sensitivity of analysis.
3 Summary and Explanation
Catecholamines include dopamine (found mostly in the central nervous system), norepinephrine (mainly in the sympathetic nervous system) and epinephrine (mainly in the adrenal medulla). They are stored as inactive complex. Released catecholamines, having a short half-life, are taken up by sympathetic nerve endings, or metabolized by the liver and kidney and excreted.
Vanillylmandelic acid (VMA) and 4-hydroxy-3-methoxy-mandelic acid (HMMA) are the end product of both epinephrine and norepinephrine catabolism. Quantitation of the acidic metabolites has long proven to be a reliable diagnostic as well as commonly used follow-up procedure for pheochromocytoma and other catecholamine-, producing tumors (14-16). The prevalence of pheochromocytoma is 0.1% to 0.2% of hypertensive patients (17, 18). Pheochromocytomas have a long record of misdiagnosis due to the metabolic, cardia and gastrointestinal symptoms that can mimic many other diseases. Undetected, or mistreated it can be fatal. However, since this is a surgically curable disease, early diagnosis by demonstration of excess VMA excretion is critically important.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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