產品名稱：Cortisol ELISA
產    地：Demeditec 
產品貨號：DE1887
產品規格：96 Tests
產品說明：
Special remarks:  Cortisol (hydrocortisone, compound F) is the main corticosteroid secreted in humans by the adrenal cortex. This steroid hormone has a molecular weight of 363.5.
In most physiological conditions, only about 10% of plasma cortisol circulates unbound from transcortin and albumin. Among the products of the human adrenal cortex, only cortisol is involved in the regulation of ACTH secretion.
As the level of free (non-protein bound) cortisol in blood rises, the release of ACTH is inhibited by the negative feedback effect. Conversely, if cortisol levels are subnormal, the negative feedback decreases, ACTH levels rise, and the adrenal cortex secretes cortisol until normal blood levels are restored.
The release of ACTH is under control of hypothalamic corticotrophin-releasing hormone (CRH); the negative feedback system involving cortisol has been identified at both hypothalamic and pituitary levels.
Normally during the day there is a fluctuation of cortisol achieving the highest level in the morning and the lowest in the night. Useful information is given when cortisol measurement is done in samples withdrawn at a fixed hour (8.00 a.m.). The main biological effects of cortisol are:  promotion of gluconeogenesis, deposition of liver glycogen, increase in blood glucose concentration when the carbohydrate utilization is reduced, effect on fat metabolism and anti-inflammatory action.
Cortisol measurement is a powerful tool for the evaluation of suspected abnormalities in glucocorticoid production: Cushing’s Syndrome (hypercortisolism), Addison’s disease or secondary adrenal insufficiency (hypocortisolism).  In many cases, it is necessary to perform dynamic tests (suppression or stimulation) in order to localize the defect at one of the three main levels (i.e. adrenal, pituitary, hypothalamus).
The above test kits measures the total (unconjugated) Cortisol in serum. There is also a method available for the measurement of free Cortisol in saliva. The metabolic activity of any steroid is just represented by the free hormone fraction which represents less than 5% of the total. The non-invasive sampling of saliva samples offers another advantage of salivary testing. Demeditec is offering such a testkit in ELISA format with the catalogue number DES6611.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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