產品名稱：FSH IRMA
產    地：Demeditec
產品貨號：DE31100
產品規格：100 Tests
產品說明：
Special remarks:
Introduction
The Follicle Stimulating Hormone (Follitropin or hFSH) is a glycoprotein with a molecular weight of 30000, secreted by the adenohypophysis. Like other glycoprotein hormones (LH, TSH and HCG), hFSH contains two different subunits, an a-and a b-chain, linked by noncovalent bounds. The primary structures of the a subunits of hFSH and of those mentioned are virtually identical, whilst their b subunits are different. The b subunits are responsible for the immunological and biological specificity of these hormones. The hFSH synthesis and release is stimulated by the hypothalamic Gonadotrophin-Releasing Hormone (GnRH), whereas the ovarian steroids secreted from the corpus luteum control further secretions of hFSH by negative feed-back. The measurement of hFSH concentrations is an important part of the investigation of disorders of the hypothalamic-pituitary-gonadal axis. It is recommended to measure both hFSH and hLH to discriminate between hypothalamic and pituitary dysfunction.
Principle of method
The technology uses two high affinity monoclonal antibodies in an immunoradiometric assay (IRMA) system. The 125I labelled signal-antibody binds to an epitope of the FSH molecule spatially different from that recognized by the biotin-capture-antibody. The two antibodies react simultaneously with the antigen present in standards or samples, which leads to the formation of a capture antibody - antigen - signal antibody complex, also referred to as a “sandwich”. During a 2-hour incubation period with shaking immuno-complex is immobilized to the reactive surface of streptavidin coated test tubes. Reaction mixture is then discarded, test tubes washed exhaustively, and the radioactivity is measured in a gamma counter. The concentration of antigen is directly proportional to the radioactivity measured in test tubes. By constructing a calibration curve plotting binding values against a series of calibrators containing known amount of hFSH, the unknown concentration of hFSH in patient samples can determined
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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