產品名稱：CA 15-3 IRMA
產    地：Demeditec 
產品貨號：DE4426
產品規格：96 Tests
產品說明：
Special remarks:
CLINICAL BACKGROUND
Biological activities
The CA 15-3 antigen is a high-molecular-weight mucin glycoprotein termed MUC-1. It has been characterized with monoclonal antibodies developed against purified extracts of a membrane fraction isolated from a human breast carcinoma (clone DF3) and against human milk fat globule membrane (clone 115D8). Other names for the mucin include polymorphic epithelial mucin (PEM), epithelial membrane antigen (MEA) or episalin.
Clinical applications
This marker is most useful in evaluating the effect of treatment for women with advanced breast cancer. Elevated levels of CA15-3 are also associated with cancers of the ovary, lung and prostate, as well as non-cancerous conditions such as benign breast or ovarian disease, endometriosis, pelvic inflammatory disease and hepatitis. Pregnancy and lactation also can raise CA 15-3 levels.
PRINCIPLES OF THE METHOD
The Demeditec CA 15-3-IRMA is a two-step immunoradiometric assay based on coated?tube separation. Mab1, the capture antibody, is attached to the lower and inner surface of the plastic tube. Add calibrators or samples to the tubes. After incubation, washing removes the occasional excess of antigen. Addition of Mab2, the signal antibody labelled with 125I, will complete the system and trigger the immunological reaction. After washing, the remaining radioactivity bound to the tube reflects the antigen concentration.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。
 

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