產品名稱：hCG RIA
產    地：Demeditec 
產品貨號：DE45100
產品規格：100 Tests
產品說明：
Special remarks:
1.Description
The 125I?hCG RIA system provides direct quantitative in vitro determination of human Chorionic Gonadotrophin (hCG) in human serum. hCG can be assayed in the range of 0?250 IU/ml using 25 µl serum samples.
2.Introduction
hCG appears in the sera of pregnant women five days after the implantation of blastocyst and its concentration continually increases until the third month of the pregnancy. The maximum concentration can reach values up to 100 IU/ml. Then the hormone level drops to 25 IU/ml and stays around this value until the last trimester.
Elevated hCG concentrations can be seen in the case of trophoblastic and nontrophoblastic neoplasia, and choriocarcinoma.
This kit can  be used in the risk assessment  of Down’s Syndrome (Trisomy 21) in combination with other biochemical and ultrasound parameters as specified above, taking also into account other data like maternal age and weight and using a validated software for Down’s Syndrome risk assessment:
1.Triple test: maternal serum AFP, hCG and unconjugated Estriol determination in the second trimester of pregnancy.
2.Quadruple test: maternal serum AFP, hCG, unconjugated Estriol and Inhibin-A determination in the second trimester of pregnancy.
3.Integrated test: maternal serum PAPP-A determination and nuchal translucency (NT) thickness measurement by an ultrasound scan in the first trimester of pregnancy and maternal serum AFP, hCG, unconjugated Estriol and Inhibin-A determination in the second trimester.
3.Principle of method
This assay is based on the competition between unlabelled hCG and fixed quantity of 125I-labelled hCG for limited number of binding sites on hCG specific antibody. Allowing to react a fixed amount of tracer and antibody with different amounts of unlabelled ligand the amount of tracer bound by the antibody will be inversely proportional to the concentration of unlabelled ligand.
During 1-hour of incubation period with continuous agitation, immuno-complex is immobilized on the reactive surface of test tubes. After incubation the reaction mixture is discarded, and the radioactivity is measured in a gamma counter.
The concentration of antigen is inversely proportional to the radioactivity measured in test tubes. By plotting binding values against a series of calibrators containing known amount of hCG, a calibration curve is constructed, from which the unknown concentration of hCG in patient samples can determined.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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