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Interleukin-1β rat ELISA

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產品名稱: Interleukin-1β rat ELISA
產品型號: DE4911
產品展商: 原裝進口
產品文檔: 無相關文檔

簡單介紹

Interleukin-1β rat ELISA


Interleukin-1β rat ELISA  的詳細介紹
Interleukin-1β rat ELISA

產品名稱:Interleukin-1β rat ELISA
產    地:Demeditec 
產品貨號:DE4911
產品規格:96 Tests
產品說明:
Special remarks: Interleukin-1 (IL-1), originally described in 1972 as lymphocyte activating factor (LAF) for its effects on thymocytes, is a polypeptide cytokine with two molecular forms. Both forms appear to mediate identical ranges of biological activity which include synthesis of the acute phase proteins by hepatocytes, chemotaxis of polymorphonucleocytes, and release of polymorphonucleocytes from blood and bone marrow. These effects coined the acronym leukocyte endogenous mediator (LEM). Early researchers also called IL?1β endogenous pyrogen, and it has been shown to induce fever and is thought to contribute to wasting of muscles (PIF, proteolysis inducing factor). Other activities associated with IL-1 are the induction of Prostaglandin E2 by synovial cells and release of collagenase with resulting destruction of cartilage and bone resorption (catabolin, osteoclast activation factor). In addition, IL-1, has multiple immunological functions including enhancement of IL-2 production by T cells and activation of B-cells (BAF) and thymocytes. A true pleiotrope, IL-1 may have tumoricidal activity via its release of IL-2 and interferon gamma and be indirectly antiviral by stimulating fibroblasts to release interferon beta. In its role as mediator of sepsis, IL-1 has most recently been described as enhancing the growth of virulent E.coli.
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