產品名稱：RNP 70 Ab ELISA
產    地：Demeditec 
產品貨號：DE7490
產品規格：96 Tests
產品說明：
Special remarks:
Anti-RNP 70 is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of IgG class autoantibodies against RNP 70 in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of Systemic Lupus Erythematosus (SLE) and Mixed connective tissue disease (MCTD).
Overlap syndrome is a generic term coined to combine several inflammatory rheumatic diseases characterized by overlapping symptoms of systemic lupus erythematosus (SLE), progressive systemic scleroderma (PSS), Dermato/Polymyositis (DM/PM), rheumatoid arthritis (RA), or Sjögren's syndrome. Mixed connective tissue disease (MCTD) is a serologically well defined overlap syndrome characterized by typical clinical manifestations, distinct autoantibodies specificities and characteristic HLA constellation (i.e. DR2 and DR4). Outstanding clinical manifestation of patients suffering from MCTD is Raynaud's phenomenon with swollen fingers and hands. Additionally, the patients exhibit arthritic complaints. During the course of disease different symptoms of the distinct overlapping connective tissue diseases often emerge in patients suffering from MCTD. However, not all MCTD patients suffer those transitions. Serologically MCTD is characterized by the presence of autoantibodies directed against the 70 kDa protein (also named 60 kDa protein) of the U1-snRNP-Komplex. Up to 100% of MCTD patients manifest high titers of Anti-RNP-70 antibodies. Patients exhibiting only Anti-RNP-70 among the various antinuclear autoantibodies show the classical clinical manifestations of mixed connective tissue disease. Additionally, often SLE typical autoantibodies (e.g. Anti-dsDNA, Anti-Sm, Anti-Histone) come along in the sera of those patients. In these cases classical MCTD will proceed to SLE. The U1-snRNP molecule (its function is splicing of pre-messenger RNA) consists of a uridine rich RNA complexed with the classical RNP antigens, i.e. 70 kDa protein, protein A (33 kDa) and protein C (22 kDa). Also the Sm specific proteins are associated with this RNA. Anti-Sm antibodies are pathognomonic markers for SLE. In the DEMEDITEC Anti-RNP-70 ELISA the wells are exclusively coated with the 70 kDa protein of the U1-snRNP complex. Accordingly, this assays provides the highly specific detection of mainly MCTD associated Anti-RNP-70 autoantibodies.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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