產(chǎn)品名稱：EGF human ELISA 產(chǎn) 地：Demeditec 產(chǎn)品貨號：DE75101 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說明： Special remarks: Epidermal Growth Factor (EGF) is a 53-amino acid polypeptide originally discovered in the mouse submaxillary gland as an agent that induced precocious eyelid opening and clearly incisor eruption in the newborn mouse. EGF has been subsequently shown to elicit an array of biological responses that are mediated by specific binding to an EGF receptor tyrosine kinase located on the cell surface. EGF induces cell proliferation, regulates tissue differentiation, modulates organogenesis. Promotes angiogenesis, and accelerates wound healing. It also acts as an inhibitor of gastric acid secretion. EGF is a member of a family of EGF-related growth factors including TGF-a, heparin binding EGF-like growth factor (HB-EGF), epiregulin, amphiregulin (AR), betracellulin (BTC), neuregulin 1, 2, and 3. EGF is initially synthesized as a precursor of a 160-170 kDa glycoprotein. The mature and soluble form of EGF is a ~6 kDa protein which can be detected in many tissues and nearly all body fluids. High levels of EGF exist in some body fluids such as saliva, urine, gastric juice, and mammary and seminal fluids. EGF triggers an intracellular signalling cascade through binding to EGF receptor (also known as ErbB 1), causing changes within the target cells. The EGF receptor, a receptor tyrosine kinase, upon stimulation by EGF results in the phosphorylation of its distinct tyrosine residues and phosphorylates the adaptor protein, SHC. Subsequently, the complex activates the Ras/mitogen activated protein (MAP) kinase pathway. This cascade couples EGF stimulation to gene transcription. 上海玉博生物技術(shù)有限公司在為生命科學領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于****地位，公司提供的產(chǎn)品涵蓋了二十多個國家近五十萬種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長和更新，公司提供的產(chǎn)品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質(zhì)組學研究的認知，以及分子診斷和臨床醫(yī)學領(lǐng)域的應用。
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