產品名稱：Osteocalcin intact human
產    地：Demeditec 
產品貨號：DEBT460
產品規格：96 Tests
其它產品：
Osteocalcin mid-tact human Demeditec DEBT480 96 Tests 7942
Osteocalcin rat Demeditec DEBT490 96 Tests 8602
產品說明：
Special remarks: This assay is able to quantify osteocalcin not only in human but also in bovine, canine, and monkey samples.
Osteocalcin, the vitamin K-dependent protein of bone, is a specific product of the osteoblast.  It is distinguished by its small size (5800 daltons) and the presence of gamma-carboxy-glutamic acid (Gla).  In the presence of ionic calcium, the Gla residues allow a specific conformational change in the protein which in turn promotes osteocalcin binding to bone mineral and subsequent accumulation in bone matrix.  While osteocalcin is primarily deposited into the extracellular matrix of bone, a small amount can be detected in the blood.  Circulating osteocalcin is thought to reflect that portion of newly synthesized protein that does not bind to bone but is released directly into the circulation.
Several recent studies suggest that there are various forms of osteocalcin in the circulation and that different antibodies detect different subforms or fragments of osteocalcin.  Many polyclonal antibodies detect both intact and fragmented osteocalcin.  The physiological significance of such osteocalcin fragments is unclear but they may be derived from osteoclastic resorption of matrix, osteoblastic synthesis, systemic catabolism, or all of these.
The assay measures only intact osteocalcin, which is synthesized de novo by the osteoblast, and it eliminates any potential confounding interference by circulating fragments.  The assay is a sandwich EIA which utilizes monoclonal antibodies directed toward the amino- and carboxy- terminal regions of the protein.  It recognizes only intact osteocalcin, requiring the full 49 residue protein for detection.  It is rapid, sensitive and reliable.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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