產品名稱：secretory IgA ELISA
產    地：Demeditec 
產品貨號：DEXK276
產品規格：96 Tests
產品說明：
Special remarks: In order to avoid arbitrary results we highly are recommending to always take 5 samples during a 2 hour period and measure the average value of the mixture.
We are highly recommending to only use appropriate validated sampling devices like the ones from Demeditec Diagnostics (see Saliva Set in this catalogue).
We also are supplying special devices for saliva sampling in newborns and babies. These are small soft plastic Pasteur pipettes. Please contact us for details.
IgA represents about 15% to 20% of immunoglobulins in the blood, although it is primarily secreted across the mucosal tract into the stomach and intestines. This prevents microbes from binding to epithelial cells in the digestive and respiratory tracts. This immunoglobulin helps to fight against pathogens that contact the body surface, are ingested, or are inhaled. It does not activate complement, and opsonises only weakly. Its heavy chains are of the type α. It exists in two forms, IgA1 (90%) and IgA2 (10%) that differ in the structure. IgA1 is composed like other proteins, however in IgA2 the heavy and light chains are not linked with disulfide but with noncovalent bonds. IgA1 is found in serum and made by bone marrow B cells, however IgA2 is made by B cells located in the mucosae and has been found to secrete into, colostrum, maternal milk, tears and saliva.
The IgA found in secretions have a special form. They are dimeric molecules, linked by two additional chains. One of these is the J chain (from join), which is a polypeptide of molecular mass 1,5 kD, rich with cysteine and structurally completely different from other immunoglobulin chains. This chain is formed in the antibody-secreting cells. The dimeric form of IgA in the outer secretions also has a polypeptide of the same molecular mass (1,5 kD) called the secretory chain and is produced by epithelial cells. It is also possible to find trimeric and even tetrameric IgA.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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