產品名稱：sAPP-beta Swedish Type
產    地：Demeditec 
產品貨號：JP27733
產品規格：96 Tests
產品說明：
Special remarks: Cross reactivity with sAPP beta Wild Type 0.11%, with sAPP-alpha <0.1%. This kit aso can be used for the investigation of brain tissue extract of Tg 2576 transgenic mice.
Alzheimer’s disease (AD) was first reported by A. Alzheimer, a German neuropathologist in 1906 and is considered as a major factor of dementia.  It is known that Amyloid beta (A-beta; which is major constituent of senile plaque) is cleaved from Amyloid Precursor Protein (APP; which exists in three main isoforms, APP695, APP751, and APP770) by beta-secretase and subsequent gamma-secretase. The production of soluble APP-beta (sAPP-beta) by beta-secretase cleavage corresponds to A-beta production accordingly, so it is desired to measure sAPP-beta in parallel with A-beta. In addition, it is reported that APP gene mutation exists in early-onset familial Alzheimer's disease patient.  Swedish mutation, one of the APP gene mutations, is a double mutation at positions -1 to -2 from the beta-secretase cleavage site (Lys670 --> Asn and Met671 --> Leu).  And further, it is reported that Swedish mutation elevates A-beta 40 and A-beta 42 production, and that the mutation is utilized in establishment of transgenic mice.  The measuring sAPP in Swedish type is useful for research of AD as well as in Wild type.
On the one hand, it is considered that in the metabolic pathway of APP, APP is first cleaved by alpha-secretase rather than beta-secretase normally to produce soluble APP-alpha and subsequently P3 is cleaved from the remaining C-terminal fragment by gamma-secretase.  In recent research, there are several attempt to apply the inhibitor of beta-secretase and the activation of alpha-secretase for AD treatment. As stated above, it is useful for research of AD to measure sAPP-alpha as well as sAPP-beta (Wild Type, Swedish Type).  This kit can measure sAPP-beta Swedish Type.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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